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TechCrunch+ roundup: New VC rules, AI biotech investor survey, Instagram ad case study

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Houses in the Sea Cliff neighborhood of San Francisco, California, US, on Thursday, Dec. 15, 2022. California home sales plunged this year as soaring interest rates held back buyers in the costly state. Photographer: David Paul Morris/Bloomberg via Getty Images
Image Credits: Bloomberg (opens in a new window) / Getty Images

When a cat is scared, it may hide under the couch; a startled fish will swim into a dark hole. And when humans feel uneasy, we tell ourselves stories.

An example: “growth at all costs” is a fairy tale made possible by cheap money that helped venture capitalists set expectations for founders — and each other — for years.

Similarly, “everyone needs 18-24 months of runway” is a nice motto, but when it takes three times longer to raise a round than it used to, it may no longer be useful advice.

“These ‘VCisms’ borne out of an era of plenty have permeated boardrooms and investor meetings everywhere,” notes Neotribes Ventures partner Rebecca Mitchem in a TechCrunch+ post this morning.


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Use discount code TCPLUSROUNDUP to save 20% off a one- or two-year subscription.


It’s time to ask ourselves if these VCisms are still relevant or if it’s time to change.

In a data-driven piece that looks at post-money valuations, deal sizes and dilution rates going back to 2012, Mitchem says we’re now heading into a new era where the tech industry will embrace “growth at reasonable costs.”

Founders can continue to water down their ownership by pursuing fat rounds, or they can decide to grow more slowly, which will leave everyone involved with a larger stake over time.

“While it may feel counterintuitive, given the recent market environment, the value of the equity for all parties — investors, founders and employees — is higher in the more conservative growth scenario,” says Mitchem.

Thanks very much for reading TC+ this week,

Walter Thompson
Editorial Manager, TechCrunch+
@yourprotagonist

The rules of VC are changing: Here’s what founders should be considering in the new era

6 investors discuss why AI is more than just a buzzword in biotech

Digital image of artificial intelligence human brain on black background.
Image Credits: Andriy Onufriyenko (opens in a new window) / Getty Images

Biotech firms widely use AI and machine learning to reduce R&D spending and bring products to market faster, but “the bigger question for investors is getting a better understanding of what exactly AI is attempting to model and predict,” says Shaq Vayda, principal at Lux Capital.

In her latest investor survey, Anna Heim spoke to six biotech investors about where AI creates value, short-term market shifts, and how they’d like to be approached by founders:

  • Robert Mittendorff, M.D, general partner and head of healthcare, B Capital
  • James Coates, health and human performance principal, Decisive Point
  • Shaq Vayda, principal, Lux Capital
  • Franck Lescure, partner, Elaia Partners
  • Francisco Dopazo, general partner, Humboldt Fund
  • Sarah Guo, founder, Conviction

6 investors discuss why AI is more than just a buzzword in biotech

Which Instagram ad placement is more cost-effective: Reels, Feed Posts or Stories?

Row of ice creams with different amounts of scoops
Image Credits: Jonathan Knowles (opens in a new window) / Getty Images

Consumer-facing startups are spending more on platforms like TikTok and Instagram to reach customers, but which ad products offer the best return?

In a case study based on Instagram campaigns for a site that facilitates bookings for freelance beauty professionals, digital marketer Angelina Liparteliani looked at Instagram Reels, Feed Posts and Stories.

Her highly detailed breakdown includes examples of the ads used in various campaigns, the process she used for optimizing creative materials and a cost-per-click analysis that shows how she reduced CPC from $1.51 to 17 cents.

“Definitely don’t chase trends,” advises Liparteliani. “Diversify your ad strategy, test different ideas and don’t give up if your ad doesn’t show results right away.”

Which Instagram ad placement is more cost-effective: Reels, Feed Posts or Stories?

Pitch Deck Teardown: MedCrypt’s $25M Series B deck

Image Credits: Medcrypt (opens in a new window)

Many medical devices are just as vulnerable to cybersecurity threats as other IoT products, which is why Y Combinator graduate MedCrypt creates software to protect patients.

The company predicts that manufacturers will need to secure $1 trillion of “new and legacy” devices over the next three years, a truly tantalizing TAM.

After redacting some customer adoption details, MedCrypt’s founders shared with TC+ the 12-slide deck that helped it raise a $25 million Series B:

  • Cover slide
  • Problem slide
  • Target audience/market size slide
  • Opportunity slide
  • Mission slide
  • Product slide: Vulnerability tracking
  • Product slide: Behavior monitoring
  • Product slide: Cryptography
  • Product slide: MedISAO
  • Team slide
  • Summary/traction slide

Pitch Deck Teardown: MedCrypt’s $25M Series B deck

Dear Sophie: When can I register my employee for the H-1B lottery?

lone figure at entrance to maze hedge that has an American flag at the center
Image Credits: Bryce Durbin/TechCrunch

Dear Sophie,

We’re a pre-seed startup thinking about sponsoring an early employee’s H-1B visa to stay in the U.S. and work for us.

How does the process work?

— Seeking in San Mateo

Dear Sophie: When can I register my employee for the H-1B lottery?

A guide to navigating your first 90 days as a new CISO

Red Colored Navigational Compass on Red Background Directly Above View.
Image Credits: MirageC (opens in a new window) / Getty Images

I’m used to working under pressure, but taking a job as a chief information security officer sounds extraordinarily stressful: People are far more likely to learn about your failures than your successes.

Managing the cybersecurity needs of an entire organization is “a big job that touches just about every part of the organization,” says Heather Gantt-Evans, CISO at SailPoint.

She’s written a guide for incoming CISOs that contains a framework for setting goals, creating action plans and, most importantly, documenting risk.

“The first 90 days of a new CISO’s term are critical,” writes Gantt-Evans. “They’re the best chance you’ll ever have to research, gather documentation and assess where things stand and how they can be improved.”

A guide to navigating your first 90 days as a new CISO

In a turbulent market, it’s time to get methodical about sales

Teacher preparing pencils for school day; aligning product team with product vision
Image Credits: Peter Dazeley (opens in a new window) / Getty Images

Many SaaS sales teams haven’t worked in an environment where so many customers are cutting back on spending, and it shows: When everyone’s in the mood to buy, it’s less important to develop a critical understanding of your customer’s needs.

“Sellers shouldn’t hop right into pushing features,” advises Steve Goldberg, chief revenue officer at Salesloft. “They should illustrate the unsustainable nature of a customer’s current behaviors and processes.”

In this post, Goldberg looks at MEDDPICC and design thinking, two sales methodologies that are “particularly effective when times get tough.”

In a turbulent market, it’s time to get methodical about sales

More TechCrunch

The Series C funding, which brings its total raise to around $95 million, will go toward mass production of the startup’s inaugural products

AI chip startup DEEPX secures $80M Series C at a $529M valuation 

A dust-up between Evolve Bank & Trust, Mercury and Synapse has led TabaPay to abandon its acquisition plans of troubled banking-as-a-service startup Synapse.

Infighting among fintech players has caused TabaPay to ‘pull out’ from buying bankrupt Synapse

The problem is not the media, but the message.

Apple’s ‘Crush’ ad is disgusting

The Twitter for Android client was “a demo app that Google had created and gave to us,” says Particle co-founder and ex-Twitter employee Sara Beykpour.

Google built some of the first social apps for Android, including Twitter and others

WhatsApp is updating its mobile apps for a fresh and more streamlined look, while also introducing a new “darker dark mode,” the company announced on Thursday. The messaging app says…

WhatsApp’s latest update streamlines navigation and adds a ‘darker dark mode’

Plinky lets you solve the problem of saving and organizing links from anywhere with a focus on simplicity and customization.

Plinky is an app for you to collect and organize links easily

The keynote kicks off at 10 a.m. PT on Tuesday and will offer glimpses into the latest versions of Android, Wear OS and Android TV.

Google I/O 2024: How to watch

For cancer patients, medicines administered in clinical trials can help save or extend lives. But despite thousands of trials in the United States each year, only 3% to 5% of…

Triomics raises $15M Series A to automate cancer clinical trials matching

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Eva Ho plans to step away from her position as general partner at Fika Ventures, the Los Angeles-based seed firm she co-founded in 2016. Fika told LPs of Ho’s intention…

Fika Ventures co-founder Eva Ho will step back from the firm after its current fund is deployed

In a post on Werner Vogels’ personal blog, he details Distill, an open-source app he built to transcribe and summarize conference calls.

Amazon’s CTO built a meeting-summarizing app for some reason

Paris-based Mistral AI, a startup working on open source large language models — the building block for generative AI services — has been raising money at a $6 billion valuation,…

Sources: Mistral AI raising at a $6B valuation, SoftBank ‘not in’ but DST is

You can expect plenty of AI, but probably not a lot of hardware.

Google I/O 2024: What to expect

Dating apps and other social friend-finders are being put on notice: Dating app giant Bumble is looking to make more acquisitions.

Bumble says it’s looking to M&A to drive growth

When Class founder Michael Chasen was in college, he and a buddy came up with the idea for Blackboard, an online classroom organizational tool. His original company was acquired for…

Blackboard founder transforms Zoom add-on designed for teachers into business tool

Groww, an Indian investment app, has become one of the first startups from the country to shift its domicile back home.

Groww joins the first wave of Indian startups moving domiciles back home from US

Technology giant Dell notified customers on Thursday that it experienced a data breach involving customers’ names and physical addresses. In an email seen by TechCrunch and shared by several people…

Dell discloses data breach of customers’ physical addresses

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The Israeli startup has raised $5.5M for its platform that uses “statistical AI” to generate synthetic data that it says is as good as the real thing.

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TikTok is starting to automatically label AI-generated content that was made on other platforms, the company announced on Thursday. With this change, if a creator posts content on TikTok that…

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India’s mobile payments regulator is likely to extend the deadline for imposing market share caps on the popular UPI (unified payments interface) payments rail by one to two years, sources…

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